At present, the American Diabetes Association (ADA)1 does not recognize a role for the glycemic index in the prevention of disease. On the basis of its review, diets with a low glyce- mic index may reduce postprandial glycemia but may be dif- ficult to maintain long term. The ADA holds that additional evidence to support the glycemic and lipid benefits of low– glycemic index diets is needed.1,2 Data from a later review of the literature, however, suggest that glycemic index infor- mation should be incorporated into exchanges and teach- ing materials3 specifically for disease prevention of diabetes, cardiovascular disease, inflammation, and, possibly, some cancers. In this chapter, the definitions of glycemic index and glycemic load are reviewed, and studies demonstrating their possible use in disease prevention are provided. Read more…